These drugs seem to function like diuretics, therefore how is blood pressure affected by using them?
Sunday, June 02 2013, 06:48 AM
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    Sunday, June 02 2013, 06:56 AM - #Permalink
    SGLT2 inhibitors reduce the absorbtion of sodium and glucose via this transporter located in the proximal tubule of the kidney. As a result, some sodium and water will be lost in the urine, resulting in a modest drop in blood pressure. Remember there is much redundancy in the kidney to reabsorb sodium and so a portion of the sodium may be reabsorbed in other parts of the nephron. In studes with
    [b]canagliflozin [/b]
    for example, systolic blood pressure fell 5 mmHg while diastolic fell 2 mmHg. Of course, these effects will vary in patients based on background therapy, the height of baseline blood pressure and other factors. Please see this attached figure:
    [img]images/Canagliflozin_and_Blood_Pressure.jpeg[/img]
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