UEndocrine Blog

Longer term data is now available comparing once weekly exenatide and daily insulin glargine in patients with Type II diabetes. All patients, also on various antihyperglycemics, had HbA1C between 7 and 11% and were treated with either 2 mg of weekly SC exenatide or glargine titrated to a fasting blood glucose 5.5 mmol/L.

Degludec is an ultralong-acting insulin with a half-life is >25 hours, nearly twice that of glargine (Lantus) which according to 2 new non-inferiority studies, could reduce the risk of overnight hypoglycaemia. Two studies, one evaluating 629 patients with type 1 diabetes and another with 744 patients with advanced type 2 diabetes insulin degludec was compared with insulin glargine in basal-bolus insulin regimens. In both studies, patients were treated to target and evaluated for hypoglycaemia.

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