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What are are the effects of blocking this transporter?
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UEndocrine Staff Accepted Answer
SGLT2 inhibitors block the sodium-glucose co-transporter in the proximal tubule. The resulting sodium and calorie loss results in reduction in plasma glucose and weight loss, ECF volume (and therefore blood pressure). The mechanism of action is summarized here:

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[img]http://embed.wistia.com/deliveries/4dae138c620f89f5f2486133601378d9167de1db.jpg?image_play_button=true&image_crop_resized=450x338[/img]
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Guest Accepted Answer

Hello UEndocrine Staff,

I am giving a presentation to some pharmacy students about Invokana. Could I have permission to use your slide? I think it is a very clear demonstration of the mechanism of action.

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UEndocrine Staff Accepted Answer

Hello,

Please see a complete slide deck attached below.

Dr. Jordan Weinstein

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Guest Accepted Answer
There is a very cool summary of MOA of the SGLT2 class on this site:

ukidney.com/nephrology-presentations/item/1342-sglt2-inhibition-questions-and-answers-for-an-emerging-therapy

GH
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Victoria Atess Accepted Answer
Please could I request permission to use this slide in a presentation for Diabetes Dialogue 2016?
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Hi Victoria,



Please email me drjweinstein@gmail.com



Jordan
  1. UEndocrine Staff
  2. 4 months ago
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